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Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications.A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction.Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.
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New Edition of a Classic Guide to Statistical Applications in the Biomedical SciencesIn the last decade, there have been significant changes in the way statistics is incorporated into biostatistical, medical, and public health research. Addressing the need for a modernized treatment of these statistical applications, Basic Statistics, Fourth Edition presents relevant, up-to-date coverage of research methodology using careful explanations of basic statistics and how they are used to address practical problems that arise in the medical and public health settings. Through concise and easy-to-follow presentations, readers will learn to interpret and examine data by applying common statistical tools, such as sampling, random assignment, and survival analysis.Continuing the tradition of its predecessor, this new edition outlines a thorough discussion of different kinds of studies and guides readers through the important, related decision-making processes such as determining what information is needed and planning the collections process. The book equips readers with the knowledge to carry out these practices by explaining the various types of studies that are commonly conducted in the fields of medical and public health, and how the level of evidence varies depending on the area of research. Data screening and data entry into statistical programs is explained and accompanied by illustrations of statistical analyses and graphs. Additional features of the Fourth Edition include:A new chapter on data collection that outlines the initial steps in planning biomedical and public health studiesA new chapter on nonparametric statistics that includes a discussion and application of the Sign test, the Wilcoxon Signed Rank test, and the Wilcoxon Rank Sum test and its relationship to the Mann-Whitney U testAn updated introduction to survival analysis that includes the Kaplan Meier method for graphing the survival function and a brief introduction to tests for comparing survival functionsIncorporation of modern statistical software, such as SAS, Stata, SPSS, and Minitab into the presented discussion of data analysisUpdated references at the end of each chapterBasic Statistics, Fourth Edition is an ideal book for courses on biostatistics, medicine, and public health at the upper-undergraduate and graduate levels. It is also appropriate as a reference for researchers and practitioners who would like to refresh their fundamental understanding of statistical techniques.
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