SAMe is a naturally occurring chemical found in almost every tissue and fluid in the body. It cannot be found in food. It is only produced by the body or made in a laboratory and supplemented. SAMe not only plays an important role in the immune system, it also helps maintain cell membranes. SAMe produces and breaks down certain chemicals in the body. These chemicals, such as serotonin, melatonin, and dopamine, play an important role in pain, depression, liver disease, and other conditions. According to the University of Maryland Medical Center (UMMC), there are numerous scientific studies showing that SAMe helps relieve the pain of Osteoarthritis. Clinical trials show SAMe may reduce pain and inflammation in the joints. Researchers also believe it may promote cartilage repair. Short term studies show that in adults with knee, hip, or spine Osteoarthritis, SAMe is as effective as non-steroidal anti-inflammatory drugs (NSAIDs), such as Ibuprofen and Naproxen. There has also been research on the use of SAMe in treatment of liver disease and Fibromyalgia.