Soloxine (Levothyroxine) 0.1 mg, 250 Tablets Provides thryoid replacement therapy in all conditions of inadequate production of thyroid hormones (hypothyroidism) in dogs. SOLOXINE ® Virbac (LEVOTHYROXINE SODIUM TABLETS, USP) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Description: Each SOLOXINE ® (Levothyroxine Sodium, USP) Tablet provides synthetic crystalline levothyroxine sodium (L-thyroxine). Levothyroxine Sodium Action: Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate metabolism, growth, development and differentiation of tissues. It increases the rate of energy exchange and increases the maturation rate of the epiphyses. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction. For purposes of comparison, 0.1 mg of levothyroxine sodium elicits a clinical response approximately equal to that produced by one grain (65 mg) of desiccated thyroid. Indications: Provides thyroid replacement therapy in all conditions of inadequate production of thyroid hormones. Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones levothyroxine (T4) and liothyronine (T3). Soloxine (levothyroxine sodium) will provide levothyroxine (T4) as a substrate for the physiologic deiodination to liothyronine (T3). Administration of levothyroxine sodium alone will result in complete physiologic thyroid replacement. Canine hypothyroidism is usually primary, i.e., due to atrophy of the thyroid gland. In the majority of cases the atrophy is associated with lymphocytic thyroiditis and in the remainder it is non-inflammatory and as of yet unknown etiology. Less than 10 percent of cases of hypothyroidism are secondary, i.e., due to deficiency of thyroid stimulating hormone (TSH). TSH deficiency may occur as a component of congenital hypopituitarism or as an acquired disorder in adult dogs, in which case it is invariably due to the growth of a pituitary tumor. Hypothyroidism in the Dog: Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Neutered animals of either sex are also frequently affected, regardless of age. The following are clinical signs of hypothyroidism in dogs: Lethargy, lack of endurance, increased sleeping; Reduced interest, alertness and excitability; Slow heart rate, weak apex beat and pulse, low voltage on ECG; Preference for warmth, low body temperature, cool skin; Increased body weight; Stiff and slow movements, dragging of front feet; Head tilt, disturbed balance, unilateral facial paralysis; Atrophy of epidermis, thickening of dermis; Surface and follicular hyperkeratosis, pigmentation; Puffy face, blepharoptosis, tragic expression; Dry, coarse, sparse coat, slow regrowth after clipping; Retarded turnover of hair (carpet coat of boxers); Shortening or absence of estrus, lack of libido; Dry feces, occasional diarrhea; Hypercholesterolemia; Normochromic, normocytic anemia; Elevated serum creatinine phosphokinase Contraindications: Levothyroxine sodium therapy is contraindicated in thyrotoxicosis, acute myocardial infarction and uncorrected adrenal insufficiency. Use in pregnant bitches has not been evaluated. Precautions: The effects of levothyroxine sodium therapy are slow in being manifested. Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydipsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change. Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. Use in pregnant bitches has not been evaluated. Adverse Reactions

Iodine's primary role is to keep the thyroid gland healthy and manufacturing sufficient thyroxine, a hormone that is needed throughout the body. About 50 to 60 percent of the body's iodine is stored in the thyroid gland, the rest is distributed throughout the body, especially in ovaries, breast and prostate tissue, muscles, and blood. Iodine plays an important role in many of the body's functions. Thyroid hormones control proper body metabolism that can influence energy production and body temperature. Thyroid function influences the adrenal glands, reproduction, nerve and muscle function, cellular oxygen use, the health of hair, skin, and bones and the breakdown of fats and proteins. Women require higher iodine amounts during periods of puberty and pregnancy. Insufficient iodine can lead to symptoms such as fatigue, dry skin, increased blood fats, brain fog, bowel irregularity,

Amp up your thyroid's performance with this essential mineral! Iodine's primary role is to keep the thyroid gland healthy and manufacturing sufficient thyroxine, a hormone that is needed throughout the body. About 50 to 60 percent of the body's iodine is stored in the thyroid gland, the rest is distributed throughout the body, especially in ovaries, breast and prostate tissue, muscles, and blood. Iodine plays an important role in many of the body's functions. Thyroid hormones control proper body metabolism that can influence energy production and body temperature. Thyroid function influences the adrenal glands, reproduction, nerve and muscle function, cellular oxygen use, the health of hair, skin, and bones and the breakdown of fats and proteins. Women require higher iodine amounts during periods of puberty and pregnancy. Insufficient iodine can lead to symptoms such as fatigue, dry skin, increased blood fats, brain fog, bowel irregularity, hoarseness, and delayed reflexes. Iodine is a very effective heavy metal detoxifer of mercury, lead, cadmium, aluminum and bromide. Symptoms of Deficiency Some of the symptoms of deficiency include; cold hands and feet, no energy, sleeping all the time, brittle hair, unable to concentrate, and heavy periods. When iodine is deficient, the thyroid gland enlarges, forming a goiter, as it attempts to capture more iodine for the production of thyroid hormones. Iodine deficiency causes the same symptoms as an underactive thyroid gland (hypothyroidism). The diagnosis of iodine deficiency is based on tests indicating low levels of iodine and thyroid hormones or a high level of thyroid-stimulating hormone (TSH) or on the presence of a goiter (only in adults). About the concentrate: One drop is 75% of the US RDA. However, Iodine has been maligned in mainstream medicine over the last 100 years to the degree that the current suggested RDA will barely keep a Goiter at bay. According to the latest research, the RDA of 150 micrograms is woefully inadequate. Doses of 5 or more milligrams per day are now being recommended. Our new concentrate addresses this issue and gives you the ability to increase your dose to much higher levels, when necessary, and at a much more affordable price.

Soloxine (Levothyroxine) 0.2 mg, 250 Tablets Provides thryoid replacement therapy in all conditions of inadequate production of thyroid hormones (hypothyroidism) in dogs. SOLOXINE ® Virbac (LEVOTHYROXINE SODIUM TABLETS, USP) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Description: Each SOLOXINE ® (Levothyroxine Sodium, USP) Tablet provides synthetic crystalline levothyroxine sodium (L-thyroxine). Levothyroxine Sodium Action: Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate metabolism, growth, development and differentiation of tissues. It increases the rate of energy exchange and increases the maturation rate of the epiphyses. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction. For purposes of comparison, 0.1 mg of levothyroxine sodium elicits a clinical response approximately equal to that produced by one grain (65 mg) of desiccated thyroid. Indications: Provides thyroid replacement therapy in all conditions of inadequate production of thyroid hormones. Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones levothyroxine (T4) and liothyronine (T3). Soloxine (levothyroxine sodium) will provide levothyroxine (T4) as a substrate for the physiologic deiodination to liothyronine (T3). Administration of levothyroxine sodium alone will result in complete physiologic thyroid replacement. Canine hypothyroidism is usually primary, i.e., due to atrophy of the thyroid gland. In the majority of cases the atrophy is associated with lymphocytic thyroiditis and in the remainder it is non-inflammatory and as of yet unknown etiology. Less than 10 percent of cases of hypothyroidism are secondary, i.e., due to deficiency of thyroid stimulating hormone (TSH). TSH deficiency may occur as a component of congenital hypopituitarism or as an acquired disorder in adult dogs, in which case it is invariably due to the growth of a pituitary tumor. Hypothyroidism in the Dog: Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Neutered animals of either sex are also frequently affected, regardless of age. The following are clinical signs of hypothyroidism in dogs: Lethargy, lack of endurance, increased sleeping; Reduced interest, alertness and excitability; Slow heart rate, weak apex beat and pulse, low voltage on ECG; Preference for warmth, low body temperature, cool skin; Increased body weight; Stiff and slow movements, dragging of front feet; Head tilt, disturbed balance, unilateral facial paralysis; Atrophy of epidermis, thickening of dermis; Surface and follicular hyperkeratosis, pigmentation; Puffy face, blepharoptosis, tragic expression; Dry, coarse, sparse coat, slow regrowth after clipping; Retarded turnover of hair (carpet coat of boxers); Shortening or absence of estrus, lack of libido; Dry feces, occasional diarrhea; Hypercholesterolemia; Normochromic, normocytic anemia; Elevated serum creatinine phosphokinase Contraindications: Levothyroxine sodium therapy is contraindicated in thyrotoxicosis, acute myocardial infarction and uncorrected adrenal insufficiency. Use in pregnant bitches has not been evaluated. Precautions: The effects of levothyroxine sodium therapy are slow in being manifested. Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydipsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change. Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. Use in pregnant bitches has not been evaluated. Adverse Reactions

Iodine's primary role is to keep the thyroid gland healthy and manufacturing sufficient thyroxine, a hormone that is needed throughout the body.  About 50 to 60 percent of the body's iodine is stored in the thyroid gland, the rest is distributed throughout the body, especially in ovaries, breast and prostate tissue, muscles, and blood.  Iodine plays an important role in many of the body's functions. Thyroid hormones control proper body metabolism that can influence energy production and body temperature.  Thyroid function influences the adrenal glands, reproduction, nerve and muscle function, cellular oxygen use, the health of hair, skin, and bones and the breakdown of fats and proteins. Women require higher iodine amounts during periods of puberty and pregnancy.

Thytrophin PMG 90 Tablets by Standard Process. Thytrophin PMG by Standard Process contains Protomorphogen extracts to support cellular health and Bovine thyroid PMG extract to help maintain healthy thyroid function. Contains enzyme factors, amino acids, proteins and minerals in addition to bovine thyroid PMG extract Helps support the role of the thyroid Protomorphogen extracts help provide cellular support and rehabilitation Understanding Thyroid Function The thyroid is an endocrine gland that consists of many follicles. Each follicle contains thyroglobulin, which is an iodine-containing protein that helps form thyroxine. As one of the main hormones secreted by the thyroid gland, thyroxine is important because it enhances the capability of all foods to be broken down into energy, and it also increases the protein synthesis rate within most tissues. Follicles within the thyroid also secrete a hormone called calcitonin, which helps inhibit bone re-absorption. What is Protomorphogen? Protomorphogen extract is simply a brand name that has been given to Standard Process nucleoprotein-mineral molecule extracts. These specially formulated nucleoprotein-mineral extracts promote healthy cellular division, growth and function. The Role of Bovine Thyroid PMG Whenever a tissue has been compromised, at least a dozen compounds are formed to help white blood cells reach the injury. Included in these compounds are some degenerative products of the tissue itself. The presense of these tissues activates the macrophage process, which destroys the tissue byproducts. Sometimes, the macrophages can get carried away and also destroy healthy tissue. Bovine thyroid PMG is included to help neutralize the circulating antibodies, and in turn neutralize any potential collateral cell damage which can result in healthier cells. The thyroid gland of the endocrine system secretes hormones that have a profound effect on calcium metabolism and on the entire bodys metabolic rate. Thytrophin PMG contains Protomorphogen extracts which are uniquely derived nucleoprotein-mineral extracts that support cellular health. Bovine thyroid PMG extract helps maintain the thyroid tissues in a good state of repair to support healthy thyroid function. Additional Benefits of Thytrophin PMG Thytrophin PMG contains calcium lactate, which is a highly-soluble and bioavailable form of calcium, which has a more neutral ph than other forms of calcium, so it does not require a highly acidic environment for absorption. Since calcium is so well-absorbed in Thytrophin PMG, it can easily be used by the body to support healthy functioning of the nervous system and accurate transmissions of nerve impulses. Magnesium is present in most cells of the body, but only in minute quantities. Still, it plays a large role in human metabolism (along with calcium). It helps with energy transfer, nerve excitability and muscle activity, among many other bodily functions. However, magnesium does not work alone. It must have adequate levels of calcium available for it to perform any of its various essential tasks. This is why Standard Process has included both calcium and magnesium in this whole foods supplement. These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition. Ingredients: Serving Size: 1 Tablet Calories 1 Calcium 30 mg 2% Each tablet supplies approximately 45 mg bovine thyroid PMG extract (processed to remove its thyroxine).Proprietary Blend: 109 mgMagnesium citrate and bovine thyroid PMG extract (processed to remove its thyroxine).Other Ingredients: Calcium lactate, cellulose, and calcium stearate. Dosage: One tablet per meal, or as directed

Soloxine (Levothyroxine) 0.4 mg, 250 Tablets Provides thryoid replacement therapy in all conditions of inadequate production of thyroid hormones (hypothyroidism) in dogs. SOLOXINE ® Virbac (LEVOTHYROXINE SODIUM TABLETS, USP) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Description: Each SOLOXINE ® (Levothyroxine Sodium, USP) Tablet provides synthetic crystalline levothyroxine sodium (L-thyroxine). Levothyroxine Sodium Action: Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate metabolism, growth, development and differentiation of tissues. It increases the rate of energy exchange and increases the maturation rate of the epiphyses. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction. For purposes of comparison, 0.1 mg of levothyroxine sodium elicits a clinical response approximately equal to that produced by one grain (65 mg) of desiccated thyroid. Indications: Provides thyroid replacement therapy in all conditions of inadequate production of thyroid hormones. Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones levothyroxine (T4) and liothyronine (T3). Soloxine (levothyroxine sodium) will provide levothyroxine (T4) as a substrate for the physiologic deiodination to liothyronine (T3). Administration of levothyroxine sodium alone will result in complete physiologic thyroid replacement. Canine hypothyroidism is usually primary, i.e., due to atrophy of the thyroid gland. In the majority of cases the atrophy is associated with lymphocytic thyroiditis and in the remainder it is non-inflammatory and as of yet unknown etiology. Less than 10 percent of cases of hypothyroidism are secondary, i.e., due to deficiency of thyroid stimulating hormone (TSH). TSH deficiency may occur as a component of congenital hypopituitarism or as an acquired disorder in adult dogs, in which case it is invariably due to the growth of a pituitary tumor. Hypothyroidism in the Dog: Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Neutered animals of either sex are also frequently affected, regardless of age. The following are clinical signs of hypothyroidism in dogs: Lethargy, lack of endurance, increased sleeping; Reduced interest, alertness and excitability; Slow heart rate, weak apex beat and pulse, low voltage on ECG; Preference for warmth, low body temperature, cool skin; Increased body weight; Stiff and slow movements, dragging of front feet; Head tilt, disturbed balance, unilateral facial paralysis; Atrophy of epidermis, thickening of dermis; Surface and follicular hyperkeratosis, pigmentation; Puffy face, blepharoptosis, tragic expression; Dry, coarse, sparse coat, slow regrowth after clipping; Retarded turnover of hair (carpet coat of boxers); Shortening or absence of estrus, lack of libido; Dry feces, occasional diarrhea; Hypercholesterolemia; Normochromic, normocytic anemia; Elevated serum creatinine phosphokinase Contraindications: Levothyroxine sodium therapy is contraindicated in thyrotoxicosis, acute myocardial infarction and uncorrected adrenal insufficiency. Use in pregnant bitches has not been evaluated. Precautions: The effects of levothyroxine sodium therapy are slow in being manifested. Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydipsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change. Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. Use in pregnant bitches has not been evaluated. Adverse Reactions

Lugol's Solution First developed by a French physician in 1880 named Lugol who originated a solution which contains iodine in a solution of potassium iodide. This solution has become known and used ever since as a recognized standard for dietary Iodine supplementation. Common Iodine Uses Iodine is commonly known to have a major effect on thyroid function, being a main component of the thyroid hormone thyroxine. However, Iodine has many other effects, from controlling the effects of oestrogen on breast tissue to protecting against the effects of radioactivity. Iodine has always been a huge advantage for those who want to lose weight. Iodine is the main component of thyroxine, the thyroid component which controls metabolism. As metabolic rate controls the amount of "fuel" burned by the body for energy, iodine deficiency can result in a decreased metabolic rate, hence the supplemental advantages in weight. Function of Iodine in the Human Body: 1. The mind simply works better when the body is supplied the iodine it needs. 2. Iodine is one of the best oxidizing catalysts diminishing storage of unwanted fat. 3. Thyroid gland stores iodine from the blood passing through it every 17 minute 4. Anti Pathogen like colloidal silver 5. Blood cleansing 6. Accelerates weight loss 7. Balances glandular functions particularly the thyroid

Soloxine (Levothyroxine) 0.7 mg, 250 Tablets Provides thryoid replacement therapy in all conditions of inadequate production of thyroid hormones (hypothyroidism) in dogs. SOLOXINE ® Virbac (LEVOTHYROXINE SODIUM TABLETS, USP) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Description: Each SOLOXINE ® (Levothyroxine Sodium, USP) Tablet provides synthetic crystalline levothyroxine sodium (L-thyroxine). Levothyroxine Sodium Action: Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate metabolism, growth, development and differentiation of tissues. It increases the rate of energy exchange and increases the maturation rate of the epiphyses. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction. For purposes of comparison, 0.1 mg of levothyroxine sodium elicits a clinical response approximately equal to that produced by one grain (65 mg) of desiccated thyroid. Indications: Provides thyroid replacement therapy in all conditions of inadequate production of thyroid hormones. Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones levothyroxine (T4) and liothyronine (T3). Soloxine (levothyroxine sodium) will provide levothyroxine (T4) as a substrate for the physiologic deiodination to liothyronine (T3). Administration of levothyroxine sodium alone will result in complete physiologic thyroid replacement. Canine hypothyroidism is usually primary, i.e., due to atrophy of the thyroid gland. In the majority of cases the atrophy is associated with lymphocytic thyroiditis and in the remainder it is non-inflammatory and as of yet unknown etiology. Less than 10 percent of cases of hypothyroidism are secondary, i.e., due to deficiency of thyroid stimulating hormone (TSH). TSH deficiency may occur as a component of congenital hypopituitarism or as an acquired disorder in adult dogs, in which case it is invariably due to the growth of a pituitary tumor. Hypothyroidism in the Dog: Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Neutered animals of either sex are also frequently affected, regardless of age. The following are clinical signs of hypothyroidism in dogs: Lethargy, lack of endurance, increased sleeping; Reduced interest, alertness and excitability; Slow heart rate, weak apex beat and pulse, low voltage on ECG; Preference for warmth, low body temperature, cool skin; Increased body weight; Stiff and slow movements, dragging of front feet; Head tilt, disturbed balance, unilateral facial paralysis; Atrophy of epidermis, thickening of dermis; Surface and follicular hyperkeratosis, pigmentation; Puffy face, blepharoptosis, tragic expression; Dry, coarse, sparse coat, slow regrowth after clipping; Retarded turnover of hair (carpet coat of boxers); Shortening or absence of estrus, lack of libido; Dry feces, occasional diarrhea; Hypercholesterolemia; Normochromic, normocytic anemia; Elevated serum creatinine phosphokinase Contraindications: Levothyroxine sodium therapy is contraindicated in thyrotoxicosis, acute myocardial infarction and uncorrected adrenal insufficiency. Use in pregnant bitches has not been evaluated. Precautions: The effects of levothyroxine sodium therapy are slow in being manifested. Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydipsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change. Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. Use in pregnant bitches has not been evaluated. Adverse Reactions

L-Tyrosine amino acid: is a direct precursor to Thyroxine, a primary thyroid hormone, as well as Adrenaline and Nor-adrenaline. Thyroxine hormone has been found to increase metabolism and control growth rate. Thyroid hormone helps to keep our bodies energetic and trim. This specific hormone also helps us burn fat. The spare tire that forms around our bellies at middle age is linked to declining hormone levels. Persons with a Thyroxine hormone deficiency have symptoms including excess weight gain, cold hands and feet and decreased basal metabolism. L-tyrosine nutritional supplement has been found to assist in optimizing thyroid hormone levels, increased mood, regulation of growth, metabolism, concentration and productivity. Tyrosine nutritional supplement is required for healthy skin and the maintenance of mental health. L-tyrosine supplement is recommended by practitioners as helpful for weight loss, clinical depression, Parkinson's Disease, Attention Deficit Disorder. L Tyrosine amino acid hormone enhancer supplement is used in the production of thyroid hormones and is a precursor for brain-stimulating catecholamines (dopamine, norepinephrine, and adrenaline) which support stress response mechanisms, have effect on mood and ability to concentrate* L-Tyrosine nutritional supplement improves cognitive and physical performance. This product contains pure L-Tyrosine USP 500 mg provided in vegetarian capsules. L-Tyrosine supplement dosage: Take 1 capsule a day Bottles are sealed with a new in shrink wrap for your protection This product was made in a GMP and ISO 9001:2000 registered Facility

Soloxine (Levothyroxine) 0.3 mg, 250 Tablets Provides thryoid replacement therapy in all conditions of inadequate production of thyroid hormones (hypothyroidism) in dogs. SOLOXINE ® Virbac (LEVOTHYROXINE SODIUM TABLETS, USP) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Description: Each SOLOXINE ® (Levothyroxine Sodium, USP) Tablet provides synthetic crystalline levothyroxine sodium (L-thyroxine). Levothyroxine Sodium Action: Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate metabolism, growth, development and differentiation of tissues. It increases the rate of energy exchange and increases the maturation rate of the epiphyses. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction. For purposes of comparison, 0.1 mg of levothyroxine sodium elicits a clinical response approximately equal to that produced by one grain (65 mg) of desiccated thyroid. Indications: Provides thyroid replacement therapy in all conditions of inadequate production of thyroid hormones. Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones levothyroxine (T4) and liothyronine (T3). Soloxine (levothyroxine sodium) will provide levothyroxine (T4) as a substrate for the physiologic deiodination to liothyronine (T3). Administration of levothyroxine sodium alone will result in complete physiologic thyroid replacement. Canine hypothyroidism is usually primary, i.e., due to atrophy of the thyroid gland. In the majority of cases the atrophy is associated with lymphocytic thyroiditis and in the remainder it is non-inflammatory and as of yet unknown etiology. Less than 10 percent of cases of hypothyroidism are secondary, i.e., due to deficiency of thyroid stimulating hormone (TSH). TSH deficiency may occur as a component of congenital hypopituitarism or as an acquired disorder in adult dogs, in which case it is invariably due to the growth of a pituitary tumor. Hypothyroidism in the Dog: Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Neutered animals of either sex are also frequently affected, regardless of age. The following are clinical signs of hypothyroidism in dogs: Lethargy, lack of endurance, increased sleeping; Reduced interest, alertness and excitability; Slow heart rate, weak apex beat and pulse, low voltage on ECG; Preference for warmth, low body temperature, cool skin; Increased body weight; Stiff and slow movements, dragging of front feet; Head tilt, disturbed balance, unilateral facial paralysis; Atrophy of epidermis, thickening of dermis; Surface and follicular hyperkeratosis, pigmentation; Puffy face, blepharoptosis, tragic expression; Dry, coarse, sparse coat, slow regrowth after clipping; Retarded turnover of hair (carpet coat of boxers); Shortening or absence of estrus, lack of libido; Dry feces, occasional diarrhea; Hypercholesterolemia; Normochromic, normocytic anemia; Elevated serum creatinine phosphokinase Contraindications: Levothyroxine sodium therapy is contraindicated in thyrotoxicosis, acute myocardial infarction and uncorrected adrenal insufficiency. Use in pregnant bitches has not been evaluated. Precautions: The effects of levothyroxine sodium therapy are slow in being manifested. Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydipsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change. Administer with caution to animals with clinically significant heart disease, hypertension or other complications for which a sharply increased metabolic rate might prove hazardous. Use in pregnant bitches has not been evaluated. Adverse Reactions

ThyroMedica Plus features targeted nutrients and herbs that support healthy thyroid function and facilitate the expression of thyroid hormone genes. This formula includes the key ingredient, L-Tyrosine, which serves as the foundation to nourish healthy levels of thyroxine. L-Tyrosine and iodine play a key role in the synthesis of thyroid hormones. Additionally, riboflavin, flavin adenine dinucleotide (FAD), serves as the currency of energy in the cell and facilitates the metabolic production of energy from food. Guggul and Ashwagandha may aid in the conversion of thyroxine to the more bioactive triiodothryonine (T4 to T3) and may aid in preventing free radical damage to thyroid tissue.